Buongirono, ho da poco acqusitato un dispositivo per acne/dermatitie seborroica che si chiama Sebinil e vorrei avere un parere sull'inci della crema, in particolare sull'ingrediente adelmidrol che non ho trovato su biodizionario. Grazie.
Questo è l'inci:
Aqua , Echinacea purpurea , Peg-40-Hydrogenated castor oil , Adelmidrol , Usnea Barbata , Sodium Hydroxide , Triclosan , Hyaluronic acid , Undecylenic Acid , 2-Bromo-2-Nitropropane-1,3-Diol , Biotin , Phytosphingosine , Trans-2-Dodecenedioic Acid.
Opinione inci Sebinil crema...
Moderatore: Erica Congiu
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Fabrizio Zago
- Messaggi: 16835
- Iscritto il: mar ott 05, 2004 10:38 pm
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Re: Opinione inci Sebinil crema...
Ciao neo84,
l' Adelmidrol NON è una definizione INCI quiundi il produttore NON sta seguendo quello che la Legge gli impone.
Per il resto della formulazione mi rifiuto di commentala dato che è l'esatto contrario di quello che diciamo qui.
E' pessima, dal punto di vista dell'ambiente assolutamente pessima.
La prossima volta che hai un dubbio di questo tipo consulta, preventivamente, il biodizionario.
l' Adelmidrol NON è una definizione INCI quiundi il produttore NON sta seguendo quello che la Legge gli impone.
Per il resto della formulazione mi rifiuto di commentala dato che è l'esatto contrario di quello che diciamo qui.
E' pessima, dal punto di vista dell'ambiente assolutamente pessima.
La prossima volta che hai un dubbio di questo tipo consulta, preventivamente, il biodizionario.
Re: Opinione inci Sebinil crema...
Questo è solo uno degli articoli che si trovano in rete sull'adelmidrol:
Abstract
Background: Palmitoylethanolamide (PEA) and some of its analogs have shown great efficacy in the treatment of pain and inflammation. Adelmidrol - the International Nonproprietary Name (INN) of the di-amide derivative of azelaic acid - is one of these analogs. The anti-inflammatory and analgesic effects of PEA and adelmidrol are hypothesized to be mediated, at least in part, by mast cell down-modulation. Mast cell mediators released at early stage of the inflammatory process, drive the inflammatory reaction to chronicity as it happens in lambda-carrageenin-induced granulomatous tissue formation. In the present study, the choice of testing adelmidrol depends upon the physicochemical properties of the compound, i.e. the amphipatic feature, that make it more easily soluble than PEA. Methods: In this study we investigated the effect of adelmidrol on granuloma formation induced by lambda-carrageenin-soaked sponge implant in rats. Results and Conclusion: Our results show that the local administration of the compound under study significantly decreases weight and neo-angiogenesis in granulomatous tissue. The anti-inflammatory effect was due to the modulation of mast cells degranulation, as shown by histological analysis and by the inhibition of the release of several pro-inflammatory and pro-angiogenic enzymes (e.g. iNOS, chymase and metalloproteinase MMP-9), and mediators (e.g. NO and TNF-alpha). The results indicate that adelmidrol, given locally, may represent a potential therapeutic tool in controlling chronic inflammation.
PMID: 18429935 [PubMed - as supplied by publisher]
A me pare più un medicinale che non un cosmetico.
Abstract
Background: Palmitoylethanolamide (PEA) and some of its analogs have shown great efficacy in the treatment of pain and inflammation. Adelmidrol - the International Nonproprietary Name (INN) of the di-amide derivative of azelaic acid - is one of these analogs. The anti-inflammatory and analgesic effects of PEA and adelmidrol are hypothesized to be mediated, at least in part, by mast cell down-modulation. Mast cell mediators released at early stage of the inflammatory process, drive the inflammatory reaction to chronicity as it happens in lambda-carrageenin-induced granulomatous tissue formation. In the present study, the choice of testing adelmidrol depends upon the physicochemical properties of the compound, i.e. the amphipatic feature, that make it more easily soluble than PEA. Methods: In this study we investigated the effect of adelmidrol on granuloma formation induced by lambda-carrageenin-soaked sponge implant in rats. Results and Conclusion: Our results show that the local administration of the compound under study significantly decreases weight and neo-angiogenesis in granulomatous tissue. The anti-inflammatory effect was due to the modulation of mast cells degranulation, as shown by histological analysis and by the inhibition of the release of several pro-inflammatory and pro-angiogenic enzymes (e.g. iNOS, chymase and metalloproteinase MMP-9), and mediators (e.g. NO and TNF-alpha). The results indicate that adelmidrol, given locally, may represent a potential therapeutic tool in controlling chronic inflammation.
PMID: 18429935 [PubMed - as supplied by publisher]
A me pare più un medicinale che non un cosmetico.